Resveratrol Topisch [Beitrag #284579] :: Mo., 25 November 2013 10:00
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Topisches Resveratrol sollte in der Lage sein wieder die Wnt Signal zu reaktivieren.
Contrary to the hypothesis, our study shows that the Wnt/β-catenin signaling is down-regulated in aged heart in mice. Nutrition treatment, with calorie restriction and Resveratrol supplementation, known to retard aging, opposes heart aging by restoring Wnt/β-catenin signaling level in the old heart. In addition, the expression of β-catenin gene, a key regulator of the Wnt/β-catenin signaling pathway, decreases up to 3-fold in aged heart, but is restored to levels found in young heart with methods of nutrition intervention. Combined with database search, our study suggests that some of bioflavonoids may have potential therapeutic benefits to heart aging.
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