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Akne und 17-OHP [Beitrag #13587] :: Sa., 04 März 2006 17:30 Zum vorherigen Beitrag gehen
Der Zusammenhang ist mir mittlerweile eh klar, aber schön dass es auch mal aus Dermatologie-bereichen kommt...


Journal of the American Academy of Dermatology
Volume 53, Issue 6 , December 2005, Pages 955-958

doi:10.1016/j.jaad.2005.07.014
2005 American Academy of Dermatology, Inc.
Published by Mosby, Inc.
Report

Elevated 17-hydroxyprogesterone serum values in male patients with acne

Marianne Placzek MDa, Barbara Arnold MDa, Heinrich Schmidt MDb, Sabine Gaube MDa, Elisabeth Keller PhDb, Gerd Plewig MDa and Klaus Degitz MDa, Corresponding Author Contact Information, E-mail The Corresponding Author

aFrom the Departments of Dermatology
bPediatrics, Ludwig-Maximilian-University

Accepted 5 July 2005. Munich, Germany.
Available online 5 October 2005.


Background

Androgen excess may provoke or aggravate acne by inducing seborrhea. In women,next term androgen disorders are frequently suspected when acne is accompanied by hirsutism or irregularities of the menstrual cycle. In men, however, acne may be the only sign of androgen excess.

Objective

Our aim was to investigate whether male patients with acne display pathologic androgen blood values.

Methods

This case-control study at a university dermatology department with referred and unreferred patients investigated male acne patients (n = 82, consecutive sample) in whom the diagnosis of mild to severe acne was made, as well as a control group of men without acne (n = 38). The main outcome measures were androgen parameters including morning values of testosterone, luteinizing hormone, follicle-stimulating hormone, dehydroepiandrosterone sulfate, androstenedione, and 17-hydroxyprogesterone; as well as a corticotropin stimulation test.

Results

17-Hydroxyprogesterone levels were significantly higher (P = .01) in acne patients than in the control group, whereas the other parameters did not differ significantly. In addition, the corticotropin stimulation test revealed abnormal 17-hydroxyprogesterone induction values in 10 of 82 patients.

Limitations

The analysis is limited to a selection of androgen parameters.

Conclusion

The results suggest that in men irregularities of adrenal steroid metabolism may be a factor contributing to acne.


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