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Re: Propecia und Bodybuilding [Beitrag #108910 ist eine Antwort auf Beitrag #108620] :: Mi., 13 Februar 2008 10:00  
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Michi85
Beiträge: 233 Registriert: November 2007
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Wie sieht es denn da mit den Nieren, Leber aus?
Werden diese durch die parallele Einnahme von Fin, Fluta topisch, Creatin, L-Carnitin und viel Proteine übermäßig belastet ?
03/2013: Fin 0,5mg
05/2013: 2x täglich Voltaren
06/2013: 1x täglich Progesteron topisch
Alle 2/3 Tage KET
Hin und wieder Alpicort F
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Den Beitrag einem Moderator melden
 
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Re: Propecia und Bodybuilding [Beitrag #111180 ist eine Antwort auf Beitrag #108620] :: Fr., 29 Februar 2008 03:03
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mgd81
Beiträge: 158 Registriert: November 2005
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Ich muss leider ganz klar sagen, dass ich in intensiven Trainingszeiten mehr Haare verliere!
Liegts am entstehenden Stress für den Körper, d.h. kann man mit Antioxidantien entgegenwirken?
Oder liegts dadran, dass Wachstumshormone bzw. IGF-1 keinesfalls förderlich fürs Haarwachstum sind (siehe IGF-1-Studien bzgl. Vertex-Baldness)?
Bin grad am recherchieren in den Ami-Foren und stosse dabei immer wieder auf "Insulinresistenz", die in diesem Zusammenhang ausschlaggebend sein soll, ob IGF-1-Erhöhung gut oder kontraproduktiv für die Haare ist.
Wer hat mehr, verständliche Infos zum Thema Insulin (wird immer wieder als einer von 3 AGA-Faktoren genannt:DHT, Östrogen, Insulin)?
Hier die Studien zu IGF-1:
Our findings suggest that high levels of IGF-1 may be associated with
increased risk of vertex baldness. Substantial clinical evidence
appears to support this finding. The efficacy of testosterone
treatment on hair growth in children with hypopituitarism is enhanced
by GH, the effect of which is largely mediated through IGF-1. In
adults with hypogonadism, a combination of GH and gonadotropin
treatment improves testosterone secretion and reproductive function.
It has also been recently reported that GH treatment of GH-deficient
men increases hair scores in androgen-dependent areas. These effects
can be explained either by IGF-1 directly stimulating the androgen
receptor, or by IGF-1 increasing local 5alpha-reductase activity and
thus stimulating the local conversion of testosterone to
dihydrotestosterone. It has been postulated that IGF-1 modifies
post-receptor effectors of the androgen receptor, but this is not
clearly established.
[…]
In conclusion, we have found evidence that high levels of testosterone
and IGF-1 increase the likelihood of vertex baldness, whereas neither
of these hormones appears significantly or suggestively associated
with chest hair growth. SHBG is inversely associated with vertex
baldness as well as with chest hair growth, although the association
is significant only with respect to the latter. It appears that the
effect of SHBG, if genuine, could be explained by the involvement of
this compound in the modulation of bioavailability of testosterone.”
Hormones and hair patterning in men: A role for insulin-like growth
factor 1?
Lisa B. Signorello, Joanne Wuub, Chung-cheng Hsiehb, Anastasia
Tzonouc, Dimitrios Trichopoulos, Christos S. Mantzoros
Journal of the American Academy of Dermatology
Volume 40 • Number 2 • February 1999
Copyright © 1999 American Academy of Dermatology, Inc.
“We observed that middle-aged and elderly men who reported modest to
substantial vertex balding at age 45 have lower circulating levels of
IGFBP-3 and higher levels of IGF-1 when controlling for IGFBP-3 level.
Growth factors are beginning to emerge as contributors to hair growth
and loss. IGF-1 is an abundant endocrine, paracrine, and autocrine
growth control factor that promotes proliferative activity in
epithelial and mesenchymal cells in numerous organ systems, including
the hair organ.”
[…]
“In the hair organ, IGF-1 is produced by connective tissue
constituents,10 and IGF-1 gene expression is enhanced by androgens.11
In androgen-responsive tissue, IGF-1 may act locally to positively
mediate the induction of 5-reductase by dihydrotestosterone.12 This
action of IGF-1 may be consequential for the development of balding
because conversion of testosterone to dihydrotestosterone in the scalp
by 5-reductase type 2 is essential for androgenetic alopecia.13
Indeed, oral 5-reductase type 2 inhibitors are now used to prevent
further hair loss and to induce hair regrowth in men with male pattern
balding.13 Experimental administration of the 5-reductase type 2
inhibitor finasteride results in diminished expression of IGF-1 and
its receptor and enhanced expression of IGFBP-3 in the rat prostate,
an androgen-dependent tissue.14 IGFBP-3 is the major carrier protein
that modulates the bioavailability of IGF-115 and thus may also be a
regulator of mediators of hair growth and cycle control. Our findings
are compatible with both the direct association of IGF-1 and the
modulating effect of IGFBP-3 on male pattern balding.”
[…]
“Misclassification of hair loss is possible because of self-assessment
of hair pattern up to 36 years in the past. However, there was little
correlation (r = 0.04) between age at blood draw (approximately 2
years after self-report on hair pattern) and balding at age 45,
suggesting that systematic underestimation or overestimation of the
extent of vertex balding by elderly compared with middle-aged
participants was not extensive.
The association between IGF-1 and vertex balding was only evident in
our study after adjusting for IGFBP-3, and the magnitude of the
association for IGF-1 adjusted for IGFBP-3 was not as great as shown
for IGF-1 by Signorello et al.2 Differences in the two studies that
might contribute to the disparity in the strength of the association
between IGF-1 and vertex balding include different IGF-1 assays, older
average age in the Greek study, interviewer-assessed balding in the
Greek study versus self-report in our study, and IGF-1 and balding
assessed concurrently in the Greek study versus 2 to 36 years apart in
our study. In the Greek study, adjustment for sex hormones and sex
hormone-binding globulin enhanced the risk of vertex balding
associated with IGF-1. Although not presented here because of possible
noncomparability of hormone data among the 3 samples that we included
in this analysis, adjustment for sex steroids and sex hormone-binding
globulin did not appear to alter our estimates for the relation of
vertex balding with IGF-1 or IGFBP-3. Despite these methodologic and
population differences between the two studies, both the study in
elderly Greek men2 and our study indicate that the IGF-1 axis may be
important in male pattern hair loss.”
Vertex balding, plasma insulin-like growth factor 1, and insulin-like
growth factor binding protein 3
Elizabeth A. Platz, ScD , Michael N. Pollak, MD , Walter C. Willett,
MD, DrPH, Edward Giovannucci, MD, ScD
Boston, Massachusetts, and Montreal, Canada
Journal of the American Academy of Dermatology
June 2000 • Volume 42 • Number 6
Copyright © 2000 by the American Academy of Dermatology, Inc.
1 mg Proscar (seit 04/2005)
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