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kkoo hinweis zu rauchen und HA [Beitrag #69122] :: So., 25 März 2007 13:35
kkoo Beiträge: 4429 Registriert: November 2005 Reputation: Power Member ***** Top-User	menschen sind keine mäuse, und welche mengen rauch da verwendet wurden ist auch nicht deutlich, dennoch: "Chemoprevention of smoke-induced alopecia in mice by oral administration of l-cystine and vitamin B6. D'Agostini F, Fiallo P, Pennisi TM, De Flora S. Section of Hygiene and Preventive Medicine, Department of Health Sciences, University of Genoa, Via A. Pastore 1, I-16132 Genoa, Italy. BACKGROUND: We previously demonstrated that high doses of environmental cigarette smoke (ECS) induce alopecia in mice. This effect was prevented by the oral administration of N-acetylcysteine (NAC), an analogue and precursor of l-cysteine and reduced glutathione. OBJECTIVES: The present study aimed at assessing whether l-cystine, the oxidized form of l-cysteine, which is a key hair component, may behave like NAC in inhibiting ECS-induced alopecia and modulating the mechanisms responsible for this condition. METHODS: C57BL/6 mice were exposed whole-body to ECS in a smoking machine. Groups of mice received in the diet, at three dose levels, a mixture of l-cystine with vitamin B6, which plays a role in l-cystine incorporation in hair cells. Occurrence of alopecia areas and apoptosis of hair bulb cells were evaluated for up to 6 months of exposure, and the time course induction of micronucleated erythrocytes in peripheral blood was investigated. RESULTS: The frequency of micronucleated erythrocytes was increased by ECS, irrespective of treatment with l-cystine/vitamin B6. ECS-induced alopecia and apoptosis of hair bulb cells in all exposed mice. l-Cystine/vitamin B6 inhibited alopecia in a dose-dependent fashion. CONCLUSIONS: High-dose ECS induces apoptosis-related alopecia in mice, and oral administration of l-cystine/vitamin B6 is an effective preventive treatment."
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