Startseite » Männer » Finasterid / Dutasterid » DHT Hemmer machen dick oder? Wegen Estrogen und so...
tristan ist gerade offline  tristan
icon10.gif   DHT Hemmer machen dick oder? Wegen Estrogen und so... [Beitrag #35272] :: So., 06 August 2006 04:45 Zum vorherigen Beitrag gehen
Rolling Eyes

Obesity (Silver Spring). 2006 Apr;14(4):662-72.

Dihydrotestosterone treatment results in obesity and altered lipid metabolism in orchidectomized mice.

* Moverare-Skrtic S,
* Venken K,
* Andersson N,
* Lindberg MK,
* Svensson J,
* Swanson C,
* Vanderschueren D,
* Oscarsson J,
* Gustafsson JA,
* Ohlsson C.

Center for Bone Research at the Sahlgrenska Academy (CBS), Department of Internal Medicine, Goteborg, Sweden.

OBJECTIVE: To determine the role of androgen receptor (AR) activation for adipose tissue metabolism. Sex steroids are important regulators of adipose tissue metabolism in men. Androgens may regulate the adipose tissue metabolism in men either directly by stimulation of the AR or indirectly by aromatization of androgens into estrogens and, thereafter, by stimulation of the estrogen receptors. Previous studies have shown that estrogen receptor alpha stimulation results in reduced fat mass in men. RESEARCH METHODS AND PROCEDURES: Orchidectomized mice were treated with the non-aromatizable androgen 5alpha-dihydrotestosterone (DHT), 17beta-estradiol, or vehicle. Vo(2), Vco(2), resting metabolic rate, locomotor activity, and food consumption were measured. Furthermore, changes in hepatic gene expression were analyzed. RESULTS: DHT treatment resulted in obesity, associated with reduced energy expenditure and fat oxidation. In contrast, DHT did not affect food consumption or locomotor activity. Furthermore, DHT treatment resulted in increased high-density lipoprotein-cholesterol and triglyceride levels associated with markedly decreased 7alpha-hydroxylase gene expression, indicating decreased bile acid production. DISCUSSION: We showed that AR activation results in obesity and altered lipid metabolism in orchidectomized mice. One may speculate that AR antagonists might be useful in the treatment of obesity in men.


Den Beitrag einem Moderator melden

 Eine private Nachricht an diesen Benutzer verschicken  
 
[Beitragsindex]
 
Gelesene Nachricht icon10.gif
Gelesene Nachricht icon4.gif
Gelesene Nachricht
Gelesene Nachricht
Gelesene Nachricht
Gelesene Nachricht
Vorheriges Thema: nebenwirkungen von duta!
Nächstes Thema: kurze Farge
Gehe zum Forum:
  

[ Themen als Syndikate anderen Seiten zur Verfügung stellen (XML) ] [ RSS ] [ PDF ]

aktuelle Zeit: Do. Jul 18 15:38:01 MESZ 2024

Insgesamt benötigte Zeit, um die Seite zu erzeugen: 0.00327 Sekunden
Letzte 10 Themen



Videos / Infos
Video Schuppen / seborrhoisches Ekzem


Partner Hairforlife FUE EUROPE
» Neurodermitis :: » ADS (ADHS) :: Impressum / Datenschutz
.:: Kontakt :: Forumsindex ::.

Betrieben mit: FUDforum 3.1.3.
Copyright ©2001-2023 FUDforum Bulletin Board Software