Panax Ginseng - Dkk1 Antagonist [Beitrag #402070] :: So., 24 Dezember 2017 14:58
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Zitat:It is well known that Panax ginseng (PG) has various pharmacological effects such as anti-aging and anti-inflammation. In a previous study, the authors identified that PG extract induced hair growth by means of a mechanism similar to that of minoxidil. In the present study, the inhibitory effect of PG extract on Dickkopf-1 (DKK-1)-induced catagen-like changes in hair follicles (HFs) was investigated in addition to the underlying mechanism of action. The effects of PG extract on cell proliferation, anti-apoptotic effect, and hair growth were observed using cultured outer root sheath (ORS) keratinocytes and human HFs with or without DKK-1 treatment. The PG extract significantly stimulated proliferation and inhibited apoptosis, respectively, in ORS keratinocytes. PG extract treatment affected the expression of apoptosis-related genes Bcl-2 and Bax. DKK-1 inhibited hair growth, and PG extract dramatically reversed the effect of DKK-1 on ex vivo human hair organ culture. PG extract antagonizes DKK-1-induced catagen-like changes, in part, through the regulation of apoptosis-related gene expression in HFs. These findings suggested that PG extract may reduce hair loss despite the presence of DKK-1, a strong catagen inducer via apoptosis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593495/
Wird gerade auf Reddit diskutiert, bzw. hat jemand es gepostet und alle sind still, weil sie eh nichts außer DHT kennen.
Wichtig ist, es muss wohl dieses Panax Ginseng sein. Also wer es testen will sollte seine Quelle genau überprüfen.
Evtl interessant in Kombination mit Vit C und Lithium Threonate die auch in Studien zeigten Dkk1 zu senken.
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