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pietrasch ist gerade offline  pietrasch
Placebo - Studie (indirekte Anzeichen für Fin - Wirkung) [Beitrag #166002] :: Fr., 21 August 2009 12:17 Zum vorherigen Beitrag gehen
auch nix weltbewegendes. Wenn man im Placebo-Arm, rieselt es halt schneller, aber das Fin ein bissl was kann, war den meisten ja klar...

Progression of hair loss in men with androgenetic alopecia (male pattern hair loss): long-term (5-year) controlled observational data in placebo-treated patients.
Kaufman KD, Girman CJ, Round EM, Johnson-Levonas AO, Shah AK, Rotonda J.

Merck Research Laboratories, Rahway, NJ 07065, USA. keith_kaufman@merck.com

Relatively little is known about the progression of androgenetic alopecia (AGA; male pattern hair loss) in untreated men. We evaluated the long-term (5-year) progression of AGA in men treated with placebo in a controlled clinical trial setting. We analyzed pooled data over 5 years from two replicate studies with finasteride 1 mg/day in men with predominantly vertex-pattern AGA. Each study consisted of an initial 1-year, randomized, double-blind, placebo-controlled base study and four consecutive, 1-year, double-blind, placebo-controlled extension studies. Change over time in scalp hair growth was evaluated by four predefined endpoints: scalp hair counts; assessment of standardized clinical photographs by an expert panel; investigator clinical assessment; and patient self-assessment. All four predefined endpoints demonstrated progressive scalp hair loss in men receiving placebo over the 5-year study period, with a loss of 239 hairs from baseline (26.3% decline in hair density) measured in the target area at 5 years (p < 0.001 vs. baseline). Similarly, visible progression of scalp hair loss was demonstrated by global photographic assessment, with 75% of placebo patients rated as worsened from baseline at 5 years. We found that scalp hair loss continued in a progressive manner over a 5-year period in placebo-treated men with AGA.




--ca. 0,2 mg Fin/d, seit 05/14, KET, Salix Alba Shampoo (bei SE)--
[Abgesetzt: 0,3 mg Fin/d (1/14 - 5/14), 0,4 mg Fin/d (3/12-01/14), 0,7 mg Fin/d (06/09 - 3/12), 1,25mg Fin (11/05-06/09), diverse NEMs]

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