DHT Hemmer machen dick oder? Wegen Estrogen und so... [Beitrag #35272] :: So., 06 August 2006 04:45
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tristan
Beiträge: 709 Registriert: November 2005
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Obesity (Silver Spring). 2006 Apr;14(4):662-72.
Dihydrotestosterone treatment results in obesity and altered lipid metabolism in orchidectomized mice.
* Moverare-Skrtic S,
* Venken K,
* Andersson N,
* Lindberg MK,
* Svensson J,
* Swanson C,
* Vanderschueren D,
* Oscarsson J,
* Gustafsson JA,
* Ohlsson C.
Center for Bone Research at the Sahlgrenska Academy (CBS), Department of Internal Medicine, Goteborg, Sweden.
OBJECTIVE: To determine the role of androgen receptor (AR) activation for adipose tissue metabolism. Sex steroids are important regulators of adipose tissue metabolism in men. Androgens may regulate the adipose tissue metabolism in men either directly by stimulation of the AR or indirectly by aromatization of androgens into estrogens and, thereafter, by stimulation of the estrogen receptors. Previous studies have shown that estrogen receptor alpha stimulation results in reduced fat mass in men. RESEARCH METHODS AND PROCEDURES: Orchidectomized mice were treated with the non-aromatizable androgen 5alpha-dihydrotestosterone (DHT), 17beta-estradiol, or vehicle. Vo(2), Vco(2), resting metabolic rate, locomotor activity, and food consumption were measured. Furthermore, changes in hepatic gene expression were analyzed. RESULTS: DHT treatment resulted in obesity, associated with reduced energy expenditure and fat oxidation. In contrast, DHT did not affect food consumption or locomotor activity. Furthermore, DHT treatment resulted in increased high-density lipoprotein-cholesterol and triglyceride levels associated with markedly decreased 7alpha-hydroxylase gene expression, indicating decreased bile acid production. DISCUSSION: We showed that AR activation results in obesity and altered lipid metabolism in orchidectomized mice. One may speculate that AR antagonists might be useful in the treatment of obesity in men.
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Re: DHT Hemmer machen dick oder? Wegen Estrogen und so... [Beitrag #35281 ist eine Antwort auf Beitrag #35279] :: So., 06 August 2006 10:56
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loydd
Beiträge: 1561 Registriert: Mai 2006
Power Member ***
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tut zwar vielleicht nix zur sache hier, aber ich habe in 2 WOchen 1,5 Kilo zugenommen.
Vorher 3 Jahre keinerlei Gewichtsveränderung.
Naja, nmir kanns nicht schaden.
Fincar(21.07.06)
Rogain Foam 5% (11.12.2006)Neustart: 31.07.2008
Dr.Lee Spiro Creme (Abends) (29.07.2008) abgesetzt: starker Juckreiz u. Schwellungen
H&S, Seba-Med PH-neutral Shampoo
NEMs: Biotin(10mg)
Alter: 26 NW:2,5 (frontal-Problem)
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