Metaanalyse zur Qualität von 34 klinischen Studien (Finasterid) [Beitrag #332421] :: Mo., 13 April 2015 20:53
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Adverse Event Reporting in Clinical Trials of Finasteride for Androgenic Alopecia
A Meta-analysis
http://archderm.jamanetwork.com/article.aspx?articleid=2212246
Zitat:Results Of 34 clinical trials, none had adequate safety reporting, 19 were partially adequate, 12 were inadequate, and 3 reported no adverse events. Funnel plots were asymmetric with a bias toward lower odds ratio for sexual adverse effects, suggesting systematic underdetection. No reports assessed adequacy of blinding, 18 (53%) disclosed conflicts of interest, and 19 (56%) received funding from the manufacturer. Duration of drug safety evaluation was 1 year or less for 26 of 34 trials (76%). Of 5704 men in the clinical data repository who were treated for AGA with finasteride, 1.25 mg/d or less, for AGA, only 31% met inclusion criteria for the pivotal trials referenced in the manufacturer's full prescribing information and 33% took finasteride for more than 1 year.
Conclusions and Relevance Available toxicity information from clinical trials of finasteride in men with AGA is very limited, is of poor quality, and seems to be systematically biased. In a cohort of men prescribed finasteride for routine treatment of AGA, most would have been excluded from the pivotal studies that supported US Food and Drug Administration approval for AGA. Published reports of clinical trials provide insufficient information to establish the safety profile for finasteride in the treatment of AGA.
Metaanalyse vom 1. April, vorhin im englischen Wikipedia-Artikel zu Finasterid gefunden.
Meinungen?
[Aktualisiert am: Mo., 13 April 2015 20:55]
"Der Plural von 'Anekdote' ist nicht 'Evidenz'."
- Alan I. Leshner
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Aw: Metaanalyse zur Qualität von 34 klinischen Studien (Finasterid) [Beitrag #332423 ist eine Antwort auf Beitrag #332421] :: Mo., 13 April 2015 21:17
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egal123
Beiträge: 1716 Registriert: August 2011
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Pandemonium schrieb am Mon, 13 April 2015 20:53Adverse Event Reporting in Clinical Trials of Finasteride for Androgenic Alopecia
A Meta-analysis
http://archderm.jamanetwork.com/article.aspx?articleid=2212246
Zitat:Results Of 34 clinical trials, none had adequate safety reporting, 19 were partially adequate, 12 were inadequate, and 3 reported no adverse events. Funnel plots were asymmetric with a bias toward lower odds ratio for sexual adverse effects, suggesting systematic underdetection. No reports assessed adequacy of blinding, 18 (53%) disclosed conflicts of interest, and 19 (56%) received funding from the manufacturer. Duration of drug safety evaluation was 1 year or less for 26 of 34 trials (76%). Of 5704 men in the clinical data repository who were treated for AGA with finasteride, 1.25 mg/d or less, for AGA, only 31% met inclusion criteria for the pivotal trials referenced in the manufacturer's full prescribing information and 33% took finasteride for more than 1 year.
Conclusions and Relevance Available toxicity information from clinical trials of finasteride in men with AGA is very limited, is of poor quality, and seems to be systematically biased. In a cohort of men prescribed finasteride for routine treatment of AGA, most would have been excluded from the pivotal studies that supported US Food and Drug Administration approval for AGA. Published reports of clinical trials provide insufficient information to establish the safety profile for finasteride in the treatment of AGA.
Metaanalyse vom 1. April, vorhin im englischen Wikipedia-Artikel zu Finasterid gefunden.
Meinungen?
Grandioser Fund, tausend Dank dafür
Die Metaanalyse ist sehr kritisch. Finde ich gut...Da sieht man wenigstens mal gscheit wie bei Fin-Studien gepfuscht wird. Scheinbar gibt es keine einzige richtig brauchbare Studie zu Fin u Nebenwirkungen. Da stellt sich die Frage, warum wohl? ... Im Grunde kann sich aber eh jeder selber zusammen reimen warum dies der Fall ist...
[Aktualisiert am: Mo., 13 April 2015 21:25]
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Aw: Metaanalyse zur Qualität von 34 klinischen Studien (Finasterid) [Beitrag #333404 ist eine Antwort auf Beitrag #332421] :: Fr., 24 April 2015 07:39
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pilos
Beiträge: 26785 Registriert: November 2005 Ort: Ausland
Power Member ***** Top-User
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viele studien sind nur daseinsberechtigungs-studien oder ABM's für eine armee von forschern die kein mensch braucht...
Die AGA-Behandlung ist individuell, eine Sache des "Trial And Error". Fasse dich kurz und kompakt bei Fragen... das ist meine Freizeit. Es besteht auch kein Verhältnis zu alopezie.de. ""Ich bin kein Arzt, sondern gebe hier lediglich meine private Meinung wieder; Art.5/GG. Auf Userfragen hin erläutere ich, wie ich persönlich vorgehen würde, wenn ich mich in der selben Lage befände. Bitte stets beachten: 1) Nachmachen auf eigene Gefahr und 2) Meine Vorschläge ersetzen keinen Arztbesuch!""
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