NAC - gähn - aber gut zu wissen. die quelle als schöne übersicht [Beitrag #27380] :: Sa., 03 Juni 2006 15:10 
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kkoo
Beiträge: 4429 Registriert: November 2005
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Zitat von http://members.aol.com/marykateroget/
(schöne übersicht dort. pcos hat ja vieles mit aga gemein..., zu beachten auch die regimen-tips am ende... tino wird sich freuen...)
"NAC: (N-Acetyl-Cysteine)
1800mg (take with zinc, and possibly molybdenum)
Star rating: ****
NAC is the acetylated form of the amino acid L-Cysteine. It has a study showing benefit in PCOS at 1800mg. NAC has many other studies showing benefit in diabetes. It can improve insulin sensitivity. It lowers TNF-alpha, suppresses MMP-2 and MMP-9 and inhibits VEGF. It increases Glutathione. It is a potent antioxidant. It can reduce homocysteine. It is a good idea to take amino acids on an empty stomach so they will not compete for absorption with other protein.
As of this date, there are no adequate studies of NAC administration in pregnancy.
There are at least three human studies that used 1800mg NAC which showed positive results. The first study listed below found that doses below 1200mg were beneficial, but in healthy people, 1200mg acted as a pro-oxidant and may lower glutathione. However, other studies at these doses and higher, including ones that post-date that study, found the opposite effect. Furthermore, PCOS is associated with an increased oxidative state, and if NAC can improve the parameters in PCOS, then it seems likely it would lower that oxidative stress caused by PCOS.
NAC may increase urinary zinc excretion. A molybdenum deficiency (which is very rare) can cause an accumulation of sulfite from the catabolism of L-cysteine. So, it may be a good idea to supplement zinc and molybdenum with NAC, just to insure you aren't deficient.
References: Effects of oral N-acetylcysteine on cell content and macrophage function in bronchoalveolar lavage from healthy smokers. Eur Respir J. 1988 Jul;1(7):645-50.
N-acetyl-cysteine treatment improves insulin sensitivity in women with polycystic ovary syndrome. Fertil Steril. 2002 Jun;77(6):1128-35.
Quote:"Insulin [area under curve] after [oral glucose tolerance test] was significantly reduced, and the peripheral insulin sensitivity increased after NAC administration, whereas the hepatic insulin extraction was unaffected. The NAC treatment induced a significant fall in T levels and in free androgen index values. In analyzing patients according to their insulinemic response to [oral glucose tolerance test], normoinsulinemic subjects and placebo-treated patients did not show any modification of the above parameters, whereas a significant improvement was observed in hyperinsulinemic subjects. CONCLUSION(S): NAC may be a new treatment for the improvement of insulin circulating levels and insulin sensitivity in hyperinsulinemic patients with polycystic ovary syndrome."
[Aktualisiert am: Sa., 03 Juni 2006 15:30]
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Re: NAC - gähn - aber gut nochmal zu wissen [Beitrag #27381 ist eine Antwort auf Beitrag #27380] :: Sa., 03 Juni 2006 15:20 
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glockenspiel
Beiträge: 5671 Registriert: November 2005
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| kkoo schrieb am Sam, 03 Juni 2006 15:10 |
Zitat von http://members.aol.com/marykateroget/
(schöne übersicht dort. pcos hat ja vieles mit aga gemein..., zu beachten auch die regimen-tips am ende... tino wird sich freuen...)
"NAC: (N-Acetyl-Cysteine)
1800mg (take with zinc, and possibly molybdenum)
Star rating: ****
NAC is the acetylated form of the amino acid L-Cysteine. It has a study showing benefit in PCOS at 1800mg. NAC has many other studies showing benefit in diabetes. It can improve insulin sensitivity. It lowers TNF-alpha, suppresses MMP-2 and MMP-9 and inhibits VEGF. It increases Glutathione. It is a potent antioxidant. It can reduce homocysteine. It is a good idea to take amino acids on an empty stomach so they will not compete for absorption with other protein.
As of this date, there are no adequate studies of NAC administration in pregnancy.
There are at least three human studies that used 1800mg NAC which showed positive results. The first study listed below found that doses below 1200mg were beneficial, but in healthy people, 1200mg acted as a pro-oxidant and may lower glutathione. However, other studies at these doses and higher, including ones that post-date that study, found the opposite effect. Furthermore, PCOS is associated with an increased oxidative state, and if NAC can improve the parameters in PCOS, then it seems likely it would lower that oxidative stress caused by PCOS.
NAC may increase urinary zinc excretion. A molybdenum deficiency (which is very rare) can cause an accumulation of sulfite from the catabolism of L-cysteine. So, it may be a good idea to supplement zinc and molybdenum with NAC, just to insure you aren't deficient.
References: Effects of oral N-acetylcysteine on cell content and macrophage function in bronchoalveolar lavage from healthy smokers. Eur Respir J. 1988 Jul;1(7):645-50.
N-acetyl-cysteine treatment improves insulin sensitivity in women with polycystic ovary syndrome. Fertil Steril. 2002 Jun;77(6):1128-35.
Quote:"Insulin [area under curve] after [oral glucose tolerance test] was significantly reduced, and the peripheral insulin sensitivity increased after NAC administration, whereas the hepatic insulin extraction was unaffected. The NAC treatment induced a significant fall in T levels and in free androgen index values. In analyzing patients according to their insulinemic response to [oral glucose tolerance test], normoinsulinemic subjects and placebo-treated patients did not show any modification of the above parameters, whereas a significant improvement was observed in hyperinsulinemic subjects. CONCLUSION(S): NAC may be a new treatment for the improvement of insulin circulating levels and insulin sensitivity in hyperinsulinemic patients with polycystic ovary syndrome."
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(sorry tino musste sein) 
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Re: NAC - gähn - aber gut nochmal zu wissen [Beitrag #27382 ist eine Antwort auf Beitrag #27381] :: Sa., 03 Juni 2006 15:39
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tino
Beiträge: 2762 Registriert: November 2005 Ort: Europa
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Hallo Glockenspiel
Na ja,..Mary ist auf jeden Fall ein kluges Mädchen:-)Ist sie nicht von Heralopecia?Wenn ja,..ich glaube wir haben uns schonmal gemailt.
Zitat:NAC is the acetylated form of the amino acid L-Cysteine. It has a study showing benefit in PCOS at 1800mg. NAC has many other studies showing benefit in diabetes. It can improve insulin sensitivity. It lowers TNF-alpha, suppresses MMP-2 and MMP-9 and inhibits VEGF. It increases Glutathione. It is a potent antioxidant. It can reduce homocysteine. It is a good idea to take amino acids on an empty stomach so they will not compete for absorption with other protein.
VEGF fungiert ja nur als Rettungsanker für die Endothelzellen in der Präsenz von oxidativem Stress.NAC nimmt den oxidativen Stress weg,und damit schüttet der Körper weniger rettungsanker-fungierendes VEGF aus.VEGF ist in der Präsenz von oxidativem Stress auch oft deutlich im Serum erhöht,z.b bei Dermatosen wie z.b Schuppenflechte.Diese Eigenschasft ist also auch positiv,..falls jemand was anderes glaubt...
Zitat:There are at least three human studies that used 1800mg NAC which showed positive results. The first study listed below found that doses below 1200mg were beneficial, but in healthy people, 1200mg acted as a pro-oxidant and may lower glutathione. However, other studies at these doses and higher, including ones that post-date that study, found the opposite effect. Furthermore, PCOS is associated with an increased oxidative state, and if NAC can improve the parameters in PCOS, then it seems likely it would lower that oxidative stress caused by PCOS.
Healthy people.....dort kann es villeicht may prooxidativ wirken.Wie auch Frauen mit PCO-S,sind auch Mnner mit AGA nicht so ganz healthy,...das habe ich sogar belegt,...glaube ich?Der Mann in seiner Eigenschaft als solcher ist auch schon ohne AGA ein bischen unhealty.....das ist auch belegt,...und ich glaube du kennst die Studie(Antioxidantenstatus Mann kontra Antioxidantenstatus Frau)?
Gruss Tino
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Re: NAC - gähn - aber gut nochmal zu wissen [Beitrag #27384 ist eine Antwort auf Beitrag #27382] :: Sa., 03 Juni 2006 15:58
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glockenspiel
Beiträge: 5671 Registriert: November 2005
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| Zitat: |
Healthy people.....dort kann es villeicht may prooxidativ wirken.Wie auch Frauen mit PCO-S,sind auch Mnner mit AGA nicht so ganz healthy,...das habe ich sogar belegt,...glaube ich?Der Mann in seiner Eigenschaft als solcher ist auch schon ohne AGA ein bischen unhealty.....das ist auch belegt,...und ich glaube du kennst die Studie(Antioxidantenstatus Mann kontra Antioxidantenstatus Frau)?
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ich wusste fast ganz genau, dass du das schreiben wirst  ))
öhm ich glaube die studie kenne ich, du hattest die schon mal erwähnt?
edit: ich wollte auch nicht anzweifeln, dass NAC wirken kann, ich MUSSTE dich damit nur ködern, das war zu verführerisch
[Aktualisiert am: Sa., 03 Juni 2006 15:59]
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