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kkoo l-Ascorbic acid 2-phosphate [Beitrag #166327] :: Fr., 28 August 2009 14:52
kkoo Beiträge: 4429 Registriert: November 2005 Reputation: 78 Power Member ***** Top-User	: Br J Dermatol. 2009 Jun;160(6):1157-62. Epub 2009 Mar 26. Links l-Ascorbic acid 2-phosphate promotes elongation of hair shafts via the secretion of insulin-like growth factor-1 from dermal papilla cells through phosphatidylinositol 3-kinase. Kwack MH, Shin SH, Kim SR, Im SU, Han IS, Kim MK, Kim JC, Sung YK. Department of Immunology, Kyungpook National University, Daegu, Korea. BACKGROUND: l-Ascorbic acid 2-phosphate (Asc 2-P), a derivative of l-ascorbic acid, promotes elongation of hair shafts in cultured human hair follicles and induces hair growth in mice. OBJECTIVES: To investigate whether the promotion of hair growth by Asc 2-P is mediated by insulin-like growth factor-1 (IGF-1) and, if so, to investigate the mechanism of the Asc 2-P-induced IGF-1 expression. METHODS: Dermal papilla (DP) cells were cultured and IGF-1 level was measured by reverse transcription-polymerase chain reaction and enzyme-linked immunosorbent assay after Asc 2-P treatment in the absence or presence of LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor. Also, hair shaft elongation in cultured human scalp hair follicles and proliferation of cocultured keratinocytes were examined after Asc 2-P treatment in the absence or presence of neutralizing antibody against IGF-1. In addition, keratinocyte proliferation in cultured hair follicles after Asc 2-P treatment in the absence or presence of LY294002 was examined by Ki-67 immunostaining. RESULTS: IGF-1 mRNA in DP cells was upregulated and IGF-1 protein in the conditioned medium of DP cells was significantly increased after treatment with Asc 2-P. Immunohistochemical staining showed that IGF-1 staining is increased in the DP of cultured human hair follicles by Asc 2-P. The neutralizing antibody against IGF-1 significantly suppressed the Asc 2-P-mediated elongation of hair shafts in hair follicle organ culture and significantly attenuated Asc 2-P-induced growth of cocultured keratinocytes. LY294002 significantly attenuated Asc 2-P-inducible IGF-1 expression and proliferation of follicular keratinocytes in cultured hair follicles. CONCLUSIONS: These data show that Asc 2-P-inducible IGF-1 from DP cells promotes proliferation of follicular keratinocytes and stimulates hair follicle growth in vitro via PI3K. cit. pubmed (wieder bloß über igf-1 )
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pilos

Re: l-Ascorbic acid 2-phosphate [Beitrag #166339 ist eine Antwort auf Beitrag #166327] :: Fr., 28 August 2009 16:35

pilos
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kkoo schrieb am Fre, 28 August 2009 14:52

(wieder bloß über igf-1 Dead

)

Die AGA-Behandlung ist individuell, eine Sache des "Trial And Error". Fasse dich kurz und kompakt bei Fragen... das ist meine Freizeit. Es besteht auch kein Verhältnis zu alopezie.de. ""Ich bin kein Arzt, sondern gebe hier lediglich meine private Meinung wieder; Art.5/GG. Auf Userfragen hin erläutere ich, wie ich persönlich vorgehen würde, wenn ich mich in der selben Lage befände. Bitte stets beachten: 1) Nachmachen auf eigene Gefahr und 2) Meine Vorschläge ersetzen keinen Arztbesuch!""

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