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Re: zymo hair [Beitrag #139894 ist eine Antwort auf Beitrag #139891] :: Mo., 20 Oktober 2008 12:29  
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pilos
Beiträge: 26523 Registriert: November 2005 Ort: Ausland
Power Member *****
Top-User |
alles schön rechnerei..... 
nix in vivo....
Die AGA-Behandlung ist individuell, eine Sache des "Trial And Error". Fasse dich kurz und kompakt bei Fragen... das ist meine Freizeit. Es besteht auch kein Verhältnis zu alopezie.de. ""Ich bin kein Arzt, sondern gebe hier lediglich meine private Meinung wieder; Art.5/GG. Auf Userfragen hin erläutere ich, wie ich persönlich vorgehen würde, wenn ich mich in der selben Lage befände. Bitte stets beachten: 1) Nachmachen auf eigene Gefahr und 2) Meine Vorschläge ersetzen keinen Arztbesuch!""
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Re: zymo hair [Beitrag #139895 ist eine Antwort auf Beitrag #139894] :: Mo., 20 Oktober 2008 12:37
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pippo24
Beiträge: 1160 Registriert: Januar 2006
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doch die haben auch in vivo:Aber nur zu dem ZYMO HYDROXYSTEROID DHEYDROGENASE COMPLEX
Study Design
This was a double blind study in which the 30 volunteers were randomly distributed
into two groups, each one of 15 subjects, treated with the active formulation (treatment
A) or placebo (treatment B). Treatment was twice daily (morning/evening) for 6
months.
Assessment Method
The evaluation has been made by counting the hair number and measuring hair length
in a selected area of the scalp of 25 cm2. The same area was also observed for the
general aspect and possible irritative reactions. The area was delimited by four points
indelibly marked with Dansil chloride (1-dimethylaminonaphtalene-5-sulphonyl
chloride Fluka) at the extremities of a 5x5 cm2 surface containing a hair number
between 50 and 100. On this area hairs were cut at a length of 3.5 mm by an electric
shaver passed through a squared mask 3.5 mm high leant over the delimited surface.
The evaluation was performed before the first treatment and at 15 days intervals along
the entire study period, everytime repositioning the mask over the selected area.
Product administration
The active formulation and placebo (25 mg) were contained in a sealed capsule
combined with a 10 ml vial containing distilled water to be used at each application.
The powder was dissolved in the vial at the moment of application, which was every
morning and evening. The application was preceded by careful washing of the scalp
with water at about 45°C and drying, by means of a towel, of excess water; the solution
14213ZymoHSOR doen.doc 17
(10 ml) was then distributed over the entire scalp surface and rubbed until complete
absorption of the product.
RESULTS AND CONCLUSIONS
Mean values of hair number and hair length observed during treatment with the active
formulation (treatment A) and placebo (treatment B) are depicted in the graphs below
Fig. 1 and 2).
As can be seen, treatment with the active formulation, containing the enzyme
hydroxysteroid dheydrogenase, showed a good efficacy in hair growth. In fact, in this
case, the mean value of lenght after the 6 month treatment was 8.2 mm, whereas it was
6.1 mm with the placebo treatment. These values are intended as difference between the
mean length observed at the end of treatment period and the initial value of 3.5 mm.
Observing the hair number, the mean value was almost unchanged or a little bit reduced
with the placebo (from 91 to 86), while it raised of 73%, from 84 to 145, with the
formulation containing the enzyme.
These results clearly demonstrate that the enzyme hydroxysteroid dheydrogenase is able
to reduce the amount of dihydrotestosterone which is responsible of the androgenetic
alopecia. Its total or partial removal in an acceptable time revitalizes the hair bulb
allowing hair regrowth. Of course, the efficacy is appreciable in subjects affected by
androgenetic alopecia when the degree of severity is such that a recovery is still
possible, that is to say that baldness is at its onset or at a moderate degree of severity. In
fact, in our trial it was chosen an area with a reduced number of hair instead of a
complete baldness. On the other hand, since the rationale for use is the reduction of the
excessive presence of DHT, it can be assume that the product is not effective in heathy
subjects where DHT is absent or present at a minimum amount
Finally, any irritative reaction appeared during the entire treatment period, either with
the active formulation or placebo, demonstrating the safety of the product.
Energie folgt immer dem Geist
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