Demodex-Die Milben in der Kopfhaut [Beitrag #111941] :: Do., 06 März 2008 22:12 
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Falls sich jemand fragen sollte,was Demodex eigentlich sein sollte.Demodex ist eine parasitäre Infektion der Haut und Kopfhaut.Nach Schätzungen sind ca.90 % der Bevölkerung davon betroffen,da sich die kleinen Käfer oder Milben durch springen von Kopf zu Kopf fortbewegen,sich in den Haarfolikel einnisten und dort ihre Eier legen.Dies kann bei AGA-betroffenen zu Entzündungen und Haarausfall führen,da sich die kleinen Parasiten speziell von Sebum,DHT und Hormonen ernähren und sich so prächtig vermehren können.Es wird sogar diskutiert,dass der so genannte Schorf,der sich auf der Kopfhaut bildet und leicht abgekratzt werden kann,weder abgestorbene Haut noch Talg,sondern tote Milben sein können,genau wie diese kleinen Wölbungen am Ende eines Haarschaftes,da diese sich oft dort festklammern.Damit möchte ich nicht sagen,dass jede Art von Kopfhautschuppung oder Haarausfall explizit von den Milben kommen kann,jedoch dies als Thema nicht übersehen werden sollte.
Ziemlich eklig,oder?Studien poste ich gleich noch dazu...
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Re: Demodex-Die Milben in der Kopfhaut [Beitrag #111942 ist eine Antwort auf Beitrag #111941] :: Do., 06 März 2008 22:15 
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Causes:
• Demodex species specific to humans occupy 2 periocular sites hidden from external observation. They are small in size and possess the ability to move across the skin surface.
• D folliculorum is found in hair and eyelash follicles associated with pilosebaceous glands in the eye or elsewhere on the face and the body. A single follicle may contain as many as 25 D folliculorum organisms.
• D brevis leads a much more solitary lifestyle in sebaceous glands of the body and in the meibomian gland and the gland of Zeis.
• D folliculorum measures 0.3-0.4 mm in length, whereas D brevis is one half the size of D folliculorum (0.15-0.2 mm) with similar structure of the head and the thorax but a shorter abdomen.
• The 8 legs of this arachnid are segmented and provide locomotion at a rate of 8-16 mm/h.
• D folliculorum and D brevis, also known as follicle mites, are believed to be more active in the dark, although capture in daylight is possible.
• The bright light of the day and especially the biomicroscope cause the mite to recede back into the follicle. Therefore, the mite can be observed only when an epilated lash is observed under a low-power microscope.
• The life stages of D folliculorum begin with copulation at the mouth of the follicle. Reproduction is believed to occur in darkness; a fact that is significant in symptomatology and treatment.
• Following copulation, the female burrows back into the follicle near the opening of the pilosebaceous gland and lays her eggs.
• Spickett reported the life cycle of D folliculorum and estimated that only 14.5 days elapse from ovum to adult stage, including 120 hours as an adult. Females may live an additional 5 days after oviposition.
• Sexes are separate; sexual maturity is reached in the larval form (neoteny).
• Females are territorial; they remain in their respective follicles and wait for the nomadic philandering males that travel over the surface of the skin from one follicle to another in seek of females.
• Adults reside in the follicle parallel to the hair shaft, head inward, often with the tail end (opisthosoma) protruding onto the surface of the skin at the base of the eyelash.
http://www.emedicine.com/oph/topic517.htm
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Re: Demodex-Die Milben in der Kopfhaut [Beitrag #111943 ist eine Antwort auf Beitrag #111942] :: Do., 06 März 2008 22:15
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Androgenetic alopecia: the role of inflammation and Demodex
(International Journal of Dermatology 2001, 40, 472-484)
The focus on androgenetic alopecia has been increasing in the last decade because of the availability of new, scientifically valid therapies such as Rogaine (Minoxidil) and Propecia (Finasteride). Hamilton showed in 1951, that 50% of men, and 40% of women demonstrated androgenetic alopecia by age 50.1 In 1993, 40% of men, and 30% of women showed androgenetic alopecia by age 40.2 This may re-ect the increased awareness of the problem, or interestingly might suggest that the real incidence is increasing. As our understanding evolves, the common mechanisms, including hormones, receptors, diet and supplements such as iron and B-12, all seem to play interesting and not totally understood roles. It is quite clear that manipulation of the enzyme 5 alpha reductase has a beneficial effect on this process, resulting in the great success thus far of Propecia.
Inflammation is now becoming a focus of study in the problem of alopecia, and may represent a unique opportunity for additional therapeutic approaches. We have begun some studies that suggest the role of Demodex in the process of androgenetic alopecia, and perhaps indirectly in the inflammatory response in the scalp. The Nioxin Research Center Laboratories in Atlanta conducted the initial study on 54 subjects, and showed that 53 of 54 showed increased Demodex in their alopecic scalps, either before or after cosmetic peeling. We became interested in this, and conducted our own study of 99 patients, sponsored by Nioxin Labs. In this group of healthy young adults, we saw 40 caucasian patients positive for Demodex and 32 negative. Nine African-American subjects were positive and nine were negative. All five Hispanics were positive for Demodex, while all four Asian subjects were negative. In patients with thinning hair, 87.3 tested positive for Demodex, and 12% tested negative. In subjects with normal hair, the ratio was reversed; 13.6% with Demodex present and 86.4% tested negative for Demodex. The correlation of the presence of Demodex with thinning or early alopecia at the Nioxin Research Center was higher, at 98%. Our correlation with thinning was slightly lower, at 84%.
The studies done here are minimally invasive studies, using the Nioscope, which provides magnification and visualization of the follicles, and, simply put, is a ‘follicular endoscope.’ This technique allows easy and rapid evaluation of the presence or absence of Demodex in a noninvasive technique.
Vollmer also has reported the association of Demodex, inflammation and alopecia, lending support to our hypothesis that Demodex has been long considered as a major contributor to such diseases as seborrhea, rosacea and some ophthalmologic diseases. The inflammatory reactions associated with significant Demodex infestation have been considered by some as directly related and by others as coincidental. Progressive inflammation can progress to alopecia sometimes with and sometimes without scarring. This association, if real, simply may be related to the scarring, secondary to the inflammation induced by Demodex.
The role of the inflammatory process in altering hormone metabolism is also an intriguing one that is of increasing fascination to investigators in the field of hair growth. Hormone metabolism locally is significant as the results of finasteride therapy attests. We find these initial results intriguing, suggesting that Demodex is a factor, not an epiphenomenon, and intend to follow up with these studies using sequential evaluations to determine if manipulation of the Demodex population would alter the process of progressive androgenetic alopecia. Further studies will be forthcoming.
Larry E. Millikan, MD New Orleans, LA
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Re: Demodex-Die Milben in der Kopfhaut [Beitrag #111944 ist eine Antwort auf Beitrag #111943] :: Do., 06 März 2008 22:17
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What damage can Demodex do?
Demodex mites live inside the sebaceous glands and hair follicles, sucking nutrients from the hair roots and damaging the cell walls. After mating they burrow into the skin, laying eggs, introducing bacteria and infection to the skin. Throughout the five phases of their life cycle, these mites destroy the skin by excreting wastes and secretions, laying eggs and dying within its layers. After death, their corpses become liquid and decompose inside the skin.
Research indicates that human demodex is a conditional-pathogenic parasite. The disorder occurs as the result of a large infestation of demodex mites on the skin, combined with a weakened immune system. The physical, chemical and mechanical stimulation of the skin from the mites can cause the immune system to react in extreme ways. Local allergic inflammation, erythema, papules and pustules are all reactions by the immune system.
The adolescent mite dermatitis and early symptoms of rosacea are frequently misdiagnosed as adolescent acne. A sample study has shown that from people with mite dermatitis (at least 60% of the population), 2.44% have rosacea; 7.56% have acne-like mite dermatitis. (See note 1.) When mite testing and the accorded treatment are not carried out, this condition causes increased damage to the normal health, structure and beauty of the skin. The destruction of the skin becomes more and more severe as the condition persists, leaving the facial skin rough and ugly.
The inflammation will repeatedly occur without timely intervention, correct diagnosis and effective therapy. Pathologic changes to the skin, such as enlarged opening of the hair follicles, widened pores, enlarged and damaged capillaries, hyperplasia of cells and even rhinophyma (growth of the nose and central facial areas) can develop.
http://www.demodexsolutions.com/
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Re: Demodex-Die Milben in der Kopfhaut [Beitrag #111945 ist eine Antwort auf Beitrag #111944] :: Do., 06 März 2008 22:18
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http://www.demodexsolutions.com/[/url]
What are the most obvious signs from demodex activity?
There are numerous different signs of demodex activity. This is not a complete list, rather it contains some of the most common cases.
One of the most obvious signs of the condition is a itching, crawling sensation on the face or (and) in the scalp, but most of the time, there is no itching at all, and people are not aware they are infested with Demodex mites. Often, the pores on the nose, forehead, chin and cheeks, become visibly larger. At a further stage, acne can develop, after some time, the facial skin can become red in places (rosacea) enlarging and damaging the capillaries, thickening the nose (brandy nose) etc.
Tickling sensation on the face. This occurs most frequently on the lower nose, forehead and cheeks, especially in the evening and night. This is the highest period of activity, usually when they mate. Many people are not aware of this tickle, because it starts gradually and it becomes an automatic reaction to scratch without noticing. You may have observed someone repeatedly scratching his face without realizing it.
Tickle on the scalp. Naturally, there can be also other conditions that give cause for scratching, like lice and dandruff. These should be ruled out in order to determine proper treatment.
Hair loss. In some cases, premature hair loss can be linked with extended demodex folliculorum activity.
Widened pores. Starts usually on the nose and cheeks.
Acne. Forms include pimples, pustules, papules, popular eruption etc.
Red skin. Usually appears on the lower sides of the nose, forehead and cheeks.
Itching eye lashes. Many times the eyelashes are thinning and falling out.
Itching eye brows.
Excess facial oils.
Demodedic rosacea.
Swollen nose.
[Aktualisiert am: Do., 06 März 2008 22:18]
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Re: Demodex-Die Milben in der Kopfhaut [Beitrag #111946 ist eine Antwort auf Beitrag #111945] :: Do., 06 März 2008 22:20
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http://www.jashbotanicals.com/articles/demodex_folliculorum. html
A Bit of Background
Demodex Folliculorum, also know as Demodicids, are a species of tiny mite that some researchers have recently identified as a profound contributor to hair loss. While we believe that there are other factors affecting those with hair loss, such as diet, genetics, and chemical laden hair care products, many researchers attribute this microscopic critter with much more than just a small role in the plight of hair loss. Demodex has also been called “face mite” as it has been commonly associated with various skin complications of the face, such as Acne Rosacea, blackheads, and other skin irritations.
Jerry Butler, professor of entomology, University of Florida Institute of Food and Agricultural Sciences, Gainesville:
"If you have high revels of hormones, you're going to have high levels of mite reproduction because these anthropods obtain their steroids from the host."
Author: Manolette R Roque, MD, General Manager, Ophthalmic Consultants Philippines Co, Chief of Service, Ocular Immunology and Uveitis, Consulting Staff, Cataract, Cornea and Refractive Surgery Service, EYE REPUBLIC Ophthalmology Clinic
Accumulation of waste material of the follicle mite may occur in affected follicles or sebaceous glands. Electron micrographs of the mite surface and feces show bacterial, viral, and rickettsial elements. Specific reports have revealed that both species pierce epithelial cells and consume cytoplasm. Only D brevis has been observed with channels burrowed to the germinal epithelium in the sebaceous glands.
[Aktualisiert am: Do., 06 März 2008 22:21]
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Re: Demodex-Die Milben in der Kopfhaut [Beitrag #111947 ist eine Antwort auf Beitrag #111946] :: Do., 06 März 2008 22:22
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Reseach Of The Anti-demodox Mites Effects Of Five Creams Made From Five Plants Volatilizable Oil Author:Chinese Journal of Aesthetic Medicine Summary by TsingHua (words: 300, Visits: 43) Published: Wednesday, June 15, 2005
http://www.shvoong.com/medicine-and-health/1596841-reseach-a nti-demodox-mites-effects/
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Objective
In order to look for the natural anti-demodex mites drugs,we have investigated the anti-demodex effects of five creams made from five different plants volatilizable oils in vitro under indoor temperature.
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Methods
Under indoor temperature 18?~26?,and relative humidity 60%~70%, demodex mites were obtained from the forehead,cheek,and nose of outpatients in our dematological department or some healthy students in our college.
Different creams were immediately added onto demodex mites and the survivals of demodex were observed under microscope. According to the results,the best drug was made into different gradient concentrations,and the anti-demodex effect was observed under microscope.
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Results
The creams made from Curcuma longa.L, flos caryophylli,eucalyptus globulus leaf, zingiber coralliaum, Litsea pungens Hemsl volatilizable oils had anti-demadex effects.The mortality of the demodex increased higher as time went on.Curcuma cream has the best anti-demodex effect .
There was remarkable differentiation in mortality and the changes of the morphologies and structures of mites between the curcuma cream and the basal cream(P<0.05).
There were no remarkable differentiations among the Curcuma longa cream,Flos caryophylli cream,Eucalyptus globulus leaf cream,Zingiber coralliaum cream and Litsena pungens Hemsl cream(P>0.05). There were correlations between the anti-demodex and the gradient concentrations.
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Conclusion
The volatilizable oils of Curcuma, Flos caryophylli,Eucalyptus globulus leaf,Zingiber coralliaum and Litsea pungens Hemsl have anti-demodex mites effects. Curcuma longa has the strongest anti-demodex mites effects.Our research work lays a foundation for clinical therapy of demodicidosis with Chinese medicine.
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Re: Demodex-Die Milben in der Kopfhaut [Beitrag #111949 ist eine Antwort auf Beitrag #111947] :: Do., 06 März 2008 22:23
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Method and compositions for treating rosacea US Patent 7078048 - July 18, 2006 http://www.patentstorm.us/patents/7078048-description.html
The present inventors believe that these microbes (demodex) cause an inflammatory reaction, analogous to the inflammation described in connection with inflammation in acne. It is believed that the inflammatory agent is excretia from the mites, a protein shed by the mite, a CD-14 binding protein carried by the mite that activates a TLR (toll-like receptor), or some combination thereof, and the inflammatory reaction is believed to involve AP-1, NF-.kappa.ß, and the subsequent production of MMPs in the skin.
"Accordingly, a treatment that inhibits TLR activation of NF-.kappa.ß and/or that inhibits induction of polymorphonuclear lukocytes would likely aid in the treatment of rosacea.Activation of the TLRs causes NF-.kappa.B to enter the cell nucleus of keratinocyes.
The keratinocytes are thus induced to release chemotactic factors, especially cytokines (IL-1ß, IL-8, IL-10, TNFa). These factors activate the AP-1 and NF-.kappa.B pathways, and NF-.kappa.B activates more IL-1 and TNFa (a cyclical process, such as in FIG. 1 of U.S. Pat. No. 5,837,224 on photoaging due to UV radiation).
The release of these factors causes inflammation, including the recruitment of neutrophils (PMNs; i.e., polymorphonuclear leukocytes) from the blood supply to the area from which the signallying was sent; MMP-8 and elastase are preformed in the neutrophils and so when the neutrophils arrive at the site of the rosacea, these dermal matrix-degrading enzymes arrive at the area.
The cytokines also effect other keratinocytes and fibroblasts (FB), which are resident in the skin, to generate MMPs.
This inflammatory response can directly induce MMPs. The NF-.kappa.ß from the TLR causes cells to produce inflammatory cytokines, such as TNFa, IL-1ß, IL-8, and/or IL-10. TNFa and IL-1ß, acting through NF-.kappa.ß, can induce keratinocytes and fibroblasts to produce MMPs.
The present therapy includes as an adjunct to oral isotretinoin therapy or antimicrobial therapy an inhibitor of NF-.kappa.ß
Curcumin, which inhibits both AP-1 and NF-.kappa.B: Xu et al.
"Curcumin inhibits IL1 alpha and TNF-alpha induction of AP-1 and NF-.kappa.B DNA-binding activity in bone marrow stromal cells," Hematopathol Mol Hematol, vol. 11, no. 1, 1997 8 (pp. 49 62); and Pendurthi et al.,
"The dietary pigment curcumin reduces endothelial tissue factor gene expression by inhibiting binding of AP-1 to the DNA and activation of NF-kappa B," Thromb Haemost, vol. 77, no. 4, 1997 April (pp. 772 82)
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Re: Demodex-Die Milben in der Kopfhaut [Beitrag #111954 ist eine Antwort auf Beitrag #111950] :: Do., 06 März 2008 22:27
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Caffeine seems a reasonable choice for mite reductions plus its studies with hair growth gives it 2 angles:
: J Allergy Clin Immunol. 1991 Jan;87(1 Pt 1):107-10.Links Caffeine, a naturally occurring acaricide.Russell DW, Fernández-Caldas E, Swanson MC, Seleznick MJ, Trudeau WL, Lockey RF. Division of Allergy and Clinical Immunology, University of South Florida College of Medicine, Tampa.
Since caffeine is a plant alkaloid that has been described as a naturally occurring insecticide, its acaricidal effect on Dermatophagoides pteronyssinus (Dp) was investigated. Twelve cultures were established by adding 30 Dp to 200 mg of Tetramin fish food and brewer's yeast (8:2 ratio); six cultures were treated with 20 mg of finely ground caffeine. All 12 cultures were incubated at 75% relative humidity, 25 degrees C, and observed during 8 weeks. Live mites were then counted under a stereoscope, cultures were extracted, and supernatants were analyzed for Der p I and Der f I allergen content with a two-site monoclonal RIA. Live mite counts in untreated cultures varied from 146 to 274 (215 +/- 47.1), and in caffeine-treated cultures from 0 to 3 (1 +/- 1.2; p less than or equal to 0.0001). Der p I concentrations in untreated cultures varied from 588 to 9000 ng/gm (3138.3 +/- 2990.8 ng/gm), and in caffeine-treated cultures from 52 to 117 ng/gm (78 +/- 23.8 ng/gm; p less than or equal to 0.01). Der p I was not detected in the food media or caffeine; Der f I was not detected in any of the cultures. Results demonstrate that caffeine inhibits mite growth and allergen production.
PMID: 1991914 [PubMed - indexed for MEDLINE]
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Re: Demodex-Die Milben in der Kopfhaut [Beitrag #111975 ist eine Antwort auf Beitrag #111972] :: Fr., 07 März 2008 00:03
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Ich würde das Thema aber auch nicht unbedingt unterbewerten.Wie gesagt,bei "gesunden" Leuten ohne AGA magst du recht haben Pippo und ich würde mir auch keine Sorgen machen,aber anders sieht es aus,wenn mein Hormonhaushalt verrückt spielt und ich eine exessivie Talgproduktion habe.Wie gesagt,dann können sich die Viecher eben unverhältnismässig vermehren und zum Problem werden.Ich denke sonst wäre das auch kein so großes Thema.Ich gebe dir aber Recht,dass die Behandlung kontinuierlich stattfinden sollte.Wir können da leider nur spekulieren und uns die Berichte angucken.Ich muss dazu aber sagen,dass sich meine Kopfhaut,seit dem ich Sandorn-Emu- und Teebaumöl in mein Shampoo tue,viel,viel besser anfühlt.kann aber auch an Fibroboost liegen
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Re: Demodex-Die Milben in der Kopfhaut [Beitrag #112831 ist eine Antwort auf Beitrag #112817] :: Do., 13 März 2008 13:10
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pilos
Beiträge: 27333 Registriert: November 2005 Ort: Ausland
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| Hammerhaar schrieb am Don, 13 März 2008 10:58 |
Glaubt ihr wirklich, dass man etwas gegen Demodex unternehmen sollte und dass es etwas gegen den HA bringen könnte?
Sorry, wenn ich das wieder aufwärme, aber mich interessieren die Meinungen dazu; vielleicht hat auch jemand Erfahrung...?
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da hast du voll recht....selbst wenn man die heute wegkriegen sollte sind sie morgen wieder da.... 
Die AGA-Behandlung ist individuell, eine Sache des "Trial And Error". Fasse dich kurz und kompakt bei Fragen... das ist meine Freizeit. Es besteht auch kein Verhältnis zu alopezie.de. ""Ich bin kein Arzt, sondern gebe hier lediglich meine private Meinung wieder; Art.5/GG. Auf Userfragen hin erläutere ich, wie ich persönlich vorgehen würde, wenn ich mich in der selben Lage befände. Bitte stets beachten: 1) Nachmachen auf eigene Gefahr und 2) Meine Vorschläge ersetzen keinen Arztbesuch!""
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...Ich denke wohl nicht,dass ihr mit diesem viel zu tun hattet... ;)Wenn doch Beschwerden gebe ich gerne weiter... 
Wird dir Pippo bestätigen können... 
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