Minox mit Effekt auf den Testosteron-Metabolismus? [Beitrag #110328] :: Fr., 22 Februar 2008 20:03 
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Keine Ahnung,ob die Studie jemandem hier schon bekannt ist.Finde ich allerdings ganz interessant... 
Minoxidil increases 17 beta-hydroxysteroid dehydrogenase and 5 alpha-reductase activity of cultured human dermal papilla cells from balding scalp.
Sato T, Tadokoro T, Sonoda T, Asada Y, Itami S, Takayasu S. Department of Dermatology, Oita Medical University, Japan.
Minoxidil is known to induce hair growth in male pattern baldness, for which development androgen plays a central role. We studied the effect of minoxidil on testosterone metabolism by cultured dermal papilla cells from balding or nonbalding scalp and dermal fibroblasts. In all three groups, 17beta-hydroxysteroid dehydrogenase activity was much higher than 5alpha-reductase activity. Minoxidil increased 17beta-hydroxysteroid dehydrogenase activity by nearly 40% (P < 0.001) in dermal papilla cells of balding scalp, whereas the effect was less marked in dermal papilla cells from nonbalding scalp and dermal fibroblasts. 5alpha-Reductase activity was also slightly increased by minoxidil in dermal papilla cells from balding scalp. Again, the effect on 5alpha-reductase activity was insignificant in the other two groups of cells. Whether such modification of testosterone metabolism in dermal papilla cells of balding scalp by minoxidil is related to its therapeutic effect remains unknown.
[Aktualisiert am: Fr., 22 Februar 2008 20:10]
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Re: Minox mit Effekt auf den Testosteron-Metabolismus? [Beitrag #110352 ist eine Antwort auf Beitrag #110328] :: Fr., 22 Februar 2008 21:17 
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pilos
Beiträge: 26501 Registriert: November 2005 Ort: Ausland
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| ParkerLewis schrieb am Fre, 22 Februar 2008 20:03 |
Keine Ahnung,ob die Studie jemandem hier schon bekannt ist.Finde ich allerdings ganz interessant...
Minoxidil increases 17 beta-hydroxysteroid dehydrogenase and 5 alpha-reductase activity of cultured human dermal papilla cells from balding scalp.
Sato T, Tadokoro T, Sonoda T, Asada Y, Itami S, Takayasu S. Department of Dermatology, Oita Medical University, Japan.
Minoxidil is known to induce hair growth in male pattern baldness, for which development androgen plays a central role. We studied the effect of minoxidil on testosterone metabolism by cultured dermal papilla cells from balding or nonbalding scalp and dermal fibroblasts. In all three groups, 17beta-hydroxysteroid dehydrogenase activity was much higher than 5alpha-reductase activity. Minoxidil increased 17beta-hydroxysteroid dehydrogenase activity by nearly 40% (P < 0.001) in dermal papilla cells of balding scalp, whereas the effect was less marked in dermal papilla cells from nonbalding scalp and dermal fibroblasts. 5alpha-Reductase activity was also slightly increased by minoxidil in dermal papilla cells from balding scalp. Again, the effect on 5alpha-reductase activity was insignificant in the other two groups of cells. Whether such modification of testosterone metabolism in dermal papilla cells of balding scalp by minoxidil is related to its therapeutic effect remains unknown.
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alter.... kalter..... kaffee........ 
würde hier schon seit jahren x-mal diskutiert.
Die AGA-Behandlung ist individuell, eine Sache des "Trial And Error". Fasse dich kurz und kompakt bei Fragen... das ist meine Freizeit. Es besteht auch kein Verhältnis zu alopezie.de. ""Ich bin kein Arzt, sondern gebe hier lediglich meine private Meinung wieder; Art.5/GG. Auf Userfragen hin erläutere ich, wie ich persönlich vorgehen würde, wenn ich mich in der selben Lage befände. Bitte stets beachten: 1) Nachmachen auf eigene Gefahr und 2) Meine Vorschläge ersetzen keinen Arztbesuch!""
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Re: Minox mit Effekt auf den Testosteron-Metabolismus? [Beitrag #110353 ist eine Antwort auf Beitrag #110328] :: Fr., 22 Februar 2008 21:20
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| ParkerLewis schrieb am Fre, 22 Februar 2008 20:03 |
Keine Ahnung,ob die Studie jemandem hier schon bekannt ist.Finde ich allerdings ganz interessant...
Minoxidil increases 17 beta-hydroxysteroid dehydrogenase and 5 alpha-reductase activity of cultured human dermal papilla cells from balding scalp.
Sato T, Tadokoro T, Sonoda T, Asada Y, Itami S, Takayasu S. Department of Dermatology, Oita Medical University, Japan.
Minoxidil is known to induce hair growth in male pattern baldness, for which development androgen plays a central role. We studied the effect of minoxidil on testosterone metabolism by cultured dermal papilla cells from balding or nonbalding scalp and dermal fibroblasts. In all three groups, 17beta-hydroxysteroid dehydrogenase activity was much higher than 5alpha-reductase activity. Minoxidil increased 17beta-hydroxysteroid dehydrogenase activity by nearly 40% (P < 0.001) in dermal papilla cells of balding scalp, whereas the effect was less marked in dermal papilla cells from nonbalding scalp and dermal fibroblasts. 5alpha-Reductase activity was also slightly increased by minoxidil in dermal papilla cells from balding scalp. Again, the effect on 5alpha-reductase activity was insignificant in the other two groups of cells. Whether such modification of testosterone metabolism in dermal papilla cells of balding scalp by minoxidil is related to its therapeutic effect remains unknown.
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Könnte, hätte, würde….. Vor allem der letzte Satz sagt ja wohl alles. Ich erlaube mir mal, diesen in verständliches Deutsch zu übersetzen:
“Ob eine solche Modifikation des Testosteron - Metabolismus in Hautzellen der von Haarausfall betroffenen Kopfhaut durch Minoxidil mit dessen therapeutischem Effekt zusammenhängt, bleibt weiterhin unbekannt.“
Ja was denn nun? Diese Erkenntnis bringt auch niemanden wirklich weiter.
Bis dann
Hans
Momentan:
2 x tägl. je 1 mg Propecia
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2 x tägl. je 3 gr Equisto Pulver für Huftiere
seit Nov. 07 1 x tägl. Nanominox
Alter: 47 Jahre
Status: Derzeit Norwood <4
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