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Minoxidil increases 17β-hydroxysteroid dehydrogenase and 5α-reductase activity of cultured human dermal papilla cells from balding scalp Toshihiro Satoa, *, Taketsugu Tadokorob, Tadashige Sonodaa, Yuji Asadaa, Satoshi Itamib and Susumu Takayasua a Department of Dermatology, Oita Medical University, Hasama-machi, Oita 879-5593, Japan b Department of Dermatology, Osaka University Medical School, Osaka, Japan 16 February 1999. Abstract Minoxidil is known to induce hair growthnext term in male pattern baldness, for which development androgen plays a central role. We studied the effect of minoxidil on testosterone metabolism by cultured dermal papilla cells from balding or nonbalding scalp and dermal fibroblasts. In all three groups, 17β-hydroxysteroid dehydrogenase activity was much higher than 5α-reductase activity. Minoxidil increased 17β-hydroxysteroid dehydrogenase activity by nearly 40% (P<0.001) in dermal papilla cells of balding scalp, whereas the effect was less marked in dermal papilla cells from nonbalding scalp and dermal fibroblasts. 5α-Reductase activity was also slightly increased by minoxidil in dermal papilla cells from balding scalp. Again, the effect on 5α-reductase activity was insignificant in the other two groups of cells. Whether such modification of testosterone metabolism in dermal papilla cells of balding scalp by minoxidil is related to its therapeutic effect remains unknown.  |
verfasst von: pilos ® 11/14/2005, 09:16:29 Ändern |
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